Webb10 nov. 2015 · Subsequently, a human recombinant chimeric AP (recAP) was developed as a pharmaceutically acceptable alternative. Here, we investigated the biodistribution and pharmacokinetics (PK) of recAP and ... P Pickkers received speaking and consultation fees from AM-Pharma, which developed the bovine intestinal AP and human recombinant ... Webb16 juli 2024 · AM-Pharma’s therapeutic candidate, recAP (recombinant Alkaline Phosphatase), is a proprietary recombinant human AP constructed from two naturally occurring human isoforms of the AP enzyme....
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Webb12 maj 2015 · Option may be exercised based on Phase II trial results for recombinant human Alkaline Phosphatase. AM-Pharma B.V., a privately held Dutch biopharmaceutical company focused on the development of recombinant human Alkaline Phosphatase (recAP ) for inflammatory diseases, and Pfizer Inc. announced recently that Pfizer has … WebbCiPTEC were pretreated with recAP (10 U mL −1 ) followed by incubation with LPS (100 µg mL −1 ) in Krebs–Henseleit buffer containing 10 mM HEPES (pH 7.4). Article Snippet: Detoxified LPS (dLPS; E . coli 055:B5; Sigma‐Aldrich, 10 µg mL−1 ) and inactive recAP (17 µg mL−1 , kind gift from AM‐Pharma ) were used as negative controls. fairlington arbor handbook
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WebbAM-Pharma has developed a proprietary recombinant human alkaline phosphatase (recAP) that is highly stable and active, and has been optimized for treating … Webb16 juli 2024 · Dutch biopharmaceutical company AM-Pharma has raised €116m from a European syndicate of new and existing investors. The funding will be used to support the initiation of a Phase III trial of its recombinant human alkaline phosphatase (recAP) therapeutic for patients with sepsis-associated acute kidney injury (SA-AKI). Allie Nawrat Webb31 mars 2024 · AM-Pharma is a clinical stage biopharmaceutical company, leading in the development of a treatment for acute kidney injury (AKI) with its innovative recombinant human Alkaline Phosphatase... fairlington appreciation society facebook