WebBackground: Lysosomotropic molecules are taken up into lysosomes in vitro and in vivo. Many drugs approved for clinical medicine are lysosomotropic agents, characterized by promoting particular effects including cytoplasmic vacuolization, increase in number and size of lysosomes, inhibition of their enzymes and accumulation of undegraded material, … WebLysosomotropic agents include kinase inhibitors such as ML-9, 179 metal nanoparticles (NPs), 180 and some pharmaceutically important drugs, which include nortriptyline, siramesine, desipramine, clomipramine, imipramine, etc. 48 The chemical structure of some of these compounds is listed in Figure 4.
Blocked Autophagy Using Lysosomotropic Agents Sensitizes …
Web30 okt. 2024 · The concept of lysosomotropic agents significantly changed numerous aspects of cellular biochemistry, biochemical pharmacology, and clinical medicine. In the … Web7 jun. 2024 · Lysosomal VPS18 as a potential target for the reversal of chemoresistance by a novel lysosomotropic agent RDN. Data are the mean ± SD; * p < 0.05, ** p < 0.01, and *** p < 0.001 Full size image hyperx cloud flight akkustand
LogP and pKa values and molecular structures of the …
Web9 feb. 2024 · Resistance to the anti-cancer effects of chemotherapeutic agents (chemoresistance) is a major issue for people living with cancer and their providers. A diverse set of cellular and inter-organellar signaling changes have been implicated in chemoresistance, but it is still unclear what processes lead to chemoresistance and … WebIntroduction. As a recognized food-grade preservative, sodium benzoate (SB), whose structure is shown in Fig. 1, is widely used in the food, cosmetic, and pharmaceutical industries [1–3].For example, in the food industry, SB is used in a variety of foods and beverages, such as salads, kimchi, carbonated beverages, jams, juices, and soy sauce, … Web16 mrt. 2024 · The purpose of these studies was to characterize the cellular impact of lysosomotropic compounds. As shown in Table 1, eight therapeutically and structurally diverse drugs, including chloroquine, fluoxetine, imipramine, dimebon, tamoxifen, chloropromazine, amitriptyline, and verapamil were selected. hyperx cloud flight 7.1 surround sound