Is carboplatin cardiotoxic
WebCarboplatin is approved to be used alone or with other drugs to treat: Ovarian cancer that is advanced. It is used with other chemotherapy as first-line treatment. It is used alone as palliative treatment for disease that has recurred (come back) after earlier chemotherapy. WebApr 4, 2024 · It is a monoclonal antibody that works by blocking a protein called programmed death-ligand 1 (PD-L1). It is part of a group of drugs called immune checkpoint inhibitors, which help to extend the amount of time a person can live with cancer or life without their cancer getting worse.
Is carboplatin cardiotoxic
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WebPARAPLATIN® (carboplatin) Injection is supplied as a sterile, pyrogen-free, 10 mg/mL aqueous solution of carboplatin. Carboplatin is a platinum coordination compound. The chemical name for carboplatin is platinum, diammine[1,1-cyclobutanedicarboxylato(2-)-O,O′]-, (SP-4-2), and carboplatin has the following structural formula: WebSep 15, 2024 · Carboplatin is an intravenously administered platinum coordination complex and alkylating agent which is used as a chemotherapeutic agent for the treatment of various cancers, mainly ovarian, head and neck and lung cancers. Carboplatin therapy is associated with a low rate of transient serum aminotransferase elevations and with rare instances of …
WebMar 24, 2009 · It has been described as 3 distinct types of cardiotoxicity. Acute or sub-acute injury is a rare form of cardiotoxicity that may occur immediately after a single dose or a course of anthracycline therapy, with clinical manifestations occurring within a … WebOct 1, 2016 · It could be argued that the cardiotoxicity observed in the present study may be due, at least in part, to carboplatin, the co-administered chemotherapeutic agent. Several publications have reported potential subtle cardiotoxic effects of carboplatin when …
WebCardiotoxicity of cancer chemotherapy agents other than anthracyclines, HER2-targeted agents, and fluoropyrimidines ... Yano S, Shimada K. Vasospastic angina after chemotherapy by with carboplatin and etoposide in a patient with lung cancer. Jpn Circ J 1996; 60:185. Sonnenblick M, Rosin A. Cardiotoxicity of interferon. A review of 44 cases. WebCarboplatin, sold under the trade name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is used by injection into a vein.. Side effects generally occur. Common side effects include low blood cell levels, …
WebApr 10, 2024 · Carboplatin works by killing, stopping, or slowing the growth of tumor cells. Giving carboplatin before surgery may shrink tumors in patients with high-risk prostate cancer with BRCA1 and BRCA2 gene mutations. ... Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have …
WebOct 6, 2016 · Acrolein is believed to be the major cause of this specific bladder toxicity. The major metabolite of ifosfamide is chloroacetaldehyde, which is directly toxic to the tubular cells [ 30, 31 ]. Both cyclophosphamide and ifosfamide can also cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH), similarly to melphalan [ 32 ]. kenneth wayne carswell texasWebCardiotoxicity is heart damage that arises from certain cancer treatments or drugs. It can develop years after cancer treatment, especially in adults who received cancer treatment during childhood. Certain types of cancer treatments have a higher risk for cardiotoxicity. kenneth wayne dockery brandon flWebCarboplatin is an anticancer drug ("antineoplastic" or "cytotoxic") chemotherapy drug. Carboplatin is classified as an "alkylating agent." What Carboplatin Is Used For: Carboplatin is used to treat ovarian cancer. Carboplatin is also used for other types of cancer, … is hydra russianWebJun 1, 2013 · Cardiotoxicity is a well known consequence of cancer chemotherapy. Cisplatin-based combinations are standard regimens in the therapy of advanced non-small cell lung cancer. Administration of cisplatin-containing chemotherapy causes significant oxidative and nitrosative stress in some patients. Cardiac blood biomarkers can be used … is hydra microscopicWebJan 1, 2024 · Ross C. Donehower. View. Show abstract. Cardiotoxicity in advanced non-small cell lung cancer patients treated with platinum and non-platinum based combinations as first-line treatment. Article ... kenneth wayne childress photosWebCardiotoxicity is heart damage that arises from certain cancer treatments or drugs. It can develop years after cancer treatment, especially in adults who received cancer treatment during childhood. Certain types of cancer treatments have a higher risk for cardiotoxicity. is hydralazine a controlled substanceWebCarboplatin may cause severe allergic reactions. If you experience an allergic reaction to carboplatin injection, it may begin within a few minutes after your infusion starts, and you may experience the following symptoms: hives; skin rash; itching; reddening of the skin; … is hydralyte safe during pregnancy