Ephrin type b receptor 2
The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. See more Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. See more Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. … See more EPH receptor B2 has been shown to interact with: • Abl gene • RAS p21 protein activator 1 • Src See more EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease See more WebBased on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol …
Ephrin type b receptor 2
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Web3.2 Ephrin/Eph Signaling. Ephrin receptor activation (Eph) occurs upon clustering induced by their membrane bound ligands. Ephrin ligands come in two flavors, depending on the manner by which they attach to the membrane. Ephrins can be attached by a glycosyl-phosphatidylinositol linkage for type A Ephrins, or a transmembrane domain for type B ... WebProtein-Ligand Binding and Molecular Recognition Database. Targets 384 . Tyrosine-protein kinase ABL1 15; Epidermal growth factor receptor 13; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 10; Mast/stem cell growth factor receptor Kit 8; Vascular endothelial growth factor receptor 2 8; Receptor-type tyrosine …
WebEphrin-B2 is a 40 kDa transmembrane protein that belongs to the Ephrin ligand family and binds the receptors EphB2, B3, and B4. The involvement of Ephrin-B2 in a range of … WebOct 2, 2024 · Ephrin type-A receptor (1-8) Ephrin type-B receptor (1,2,4,6) Epidermal growth factor receptor erbB1 Epithelial discoidin domain receptor 1 Eukaryotic translation initiation factor 2-alpha kinase 4 FAD-linked sulfhydryl oxidase ALR Fibroblast growth factor receptor (1-4) G protein-coupled receptor 44 Geminin Glucagon-like peptide 1 receptor
WebEphrin B3 receptor regulates the synthesis and release of D-serine in astrocytes, which may have important implications on synaptic transmission and plasticity. EPHB3, MASP1 and SST map to 3q26.2-q29 and may have roles in squamous cell carcinoma of the lung. EphB3-ephrin-B interaction promotes mesenchymal-to-epithelial transition (MET) by re ... WebMar 17, 2016 · Ephrin type-B receptor 2 (EphB2) is a member of the receptor tyrosine kinase family and plays an important role in learning and memory functions. In patients …
WebFeb 7, 2010 · Transmembrane-ephrin receptor activity. Specific Function. Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling …
WebOct 18, 2013 · Identification of ephrin type B receptor 2 (EphB2) as a novel autoantigen. (A) Nonpermeabilized human umbilical vein endothelial cells (HUVECs) were stained … kite hill where to buyWebFeb 7, 2010 · Transmembrane receptor protein tyrosine kinase activity. Specific Function. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as … magasin orchestra boncellesWebPharos : Target Details - EPHB2 Jump to section: close Descriptive Data Protein Summary Protein Classes IDG Development Level Summary Expression Data Protein Sequence … magasin only belgiqueEph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct c… magasin orthopedie bruxellesWebThe oncogenic role of ephrin type-B receptor 4 (EPHB4) has been reported in many types of tumors, including chronic myeloid leukemia (CML). Here, we found that CML patients have a higher EPHB4 expression level than healthy subjects. EPHB4 knockdown inhibited growth of K562 cells (a human immortalized myelogenous leukemia cell line). magasin ordinateur chicoutimiWebEphB4, also known as Htk, Myk1, Tyro11, and Mdk2, is a member of the Eph receptor tyrosine kinase family and binds Ephrin-B2. The A and B class Eph proteins have a common structural organization (1 - 4). The human EphB4 cDNA encodes a 987 amino acid precursor that includes a 15 amino acid (aa) signal sequence, a 524 aa extracellular … magasin outillage boisWeb产品信息. Recombinant human Ephrin-A3/EFNA3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Ser 213) of human Ephrin-A3/EFNA3 (Accession #NP_004943.1.) fused with and a 6×His tag at the C-terminus. Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. magasin only en france