WebMethods: DDR activation and cell viability upon γ-radiation was analyzed in gastric cells where expression of RNF43 was depleted. Response to chemotherapeutic agents 5-fluorouracil and cisplatin was analyzed in gastric cancer cell lines and xenograft tumors. WebAug 27, 2024 · Chemotherapy has limited applicability in tumor therapy because of the associated complications, including nausea, vomiting, myelosuppression and resistance. With the development of precision medicine, researchers are applying new therapies to target certain molecules within tumor cells to induce cell death.
RHOJ controls EMT-associated resistance to chemotherapy
WebMay 1, 2024 · DNA double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses (DDRs), including those helping cells recover from... WebMar 4, 2024 · Principal Conclusions: DDR gene amplification can lead to chemotherapy resistance and poor overall survival by augmenting DDR. These amplified DDR genes may serve as actionable clinical biomarkers for cancer management. Keywords: DNA damage repair; chemotherapy resistance; pharmacogenetics. © The author (s). Publication types natural remedy for parasites
Platinum-Based Chemotherapy in Metastatic Prostate Cancer With …
WebFeb 8, 2024 · DDR is a complex network that functions in different ways to target various DNA lesions, including signal transduction, transcriptional regulation, cell-cycle checkpoints, induction of apoptosis, damage … WebJun 29, 2024 · Defect in DNA damage response (DDR) is a common feature of cancer cells, which regulates tumor growth and therapeutic response. Recently, the approval of immune checkpoint blockade (ICB) for tumors … WebApr 16, 2024 · Alterations in DNA damage repair (DDR) genes occur in up to 25% of patients with metastatic castration-resistant prostate cancer (mCRPC) and may sensitize … natural remedy for penis enlargement